22 studies
## $studies
## [,1] [,2] [,3] [,4] [,5] [,6]
## [1,] 0 3 2 2 2 1
## [2,] 3 0 1 1 3 2
## [3,] 2 1 0 5 3 1
## [4,] 2 1 5 0 3 1
## [5,] 2 3 3 3 0 0
## [6,] 1 2 1 1 0 0
##
## $sz
## [,1] [,2] [,3] [,4] [,5] [,6]
## [1,] 0 7343 8752 15739 16488 392
## [2,] 7343 0 3315 9711 17893 9778
## [3,] 8752 3315 0 44974 15158 7999
## [4,] 15739 9711 44974 0 12597 10161
## [5,] 16488 17893 15158 12597 0 0
## [6,] 392 9778 7999 10161 0 0
##
## $prec
## [,1] [,2] [,3] [,4] [,5] [,6]
## [1,] 0.0000000 88.57260 58.24722 169.84441 159.4093 0.8807101
## [2,] 88.5725968 0.00000 17.29006 79.55654 414.2068 133.1968547
## [3,] 58.2472157 17.29006 0.00000 758.55565 235.2112 128.2837360
## [4,] 169.8444148 79.55654 758.55565 0.00000 125.7409 322.9350792
## [5,] 159.4092870 414.20679 235.21118 125.74095 0.0000 0.0000000
## [6,] 0.8807101 133.19685 128.28374 322.93508 0.0000 0.0000000
## $eff.studies
## [,1] [,2] [,3] [,4] [,5] [,6]
## [1,] NA 6.399267 6.197621 6.197621 6.151408 3.724947
## [2,] 6.399267 NA 5.619489 5.619489 6.352727 4.100939
## [3,] 6.197621 5.619489 NA 8.500000 7.047698 3.725881
## [4,] 6.197621 5.619489 8.500000 NA 7.047698 3.725881
## [5,] 6.151408 6.352727 7.047698 7.047698 NA 3.405458
## [6,] 3.724947 4.100939 3.725881 3.725881 3.405458 NA
##
## $eff.sz
## [,1] [,2] [,3] [,4] [,5] [,6]
## [1,] NA 26975.65 33068.58 36917.09 35049.50 17424.09
## [2,] 26975.65 NA 29904.63 33362.88 34413.48 21254.72
## [3,] 33068.58 29904.63 NA 65078.14 38825.21 22823.45
## [4,] 36917.09 33362.88 65078.14 NA 40724.69 24153.45
## [5,] 35049.50 34413.48 38825.21 40724.69 NA 18922.58
## [6,] 17424.09 21254.72 22823.45 24153.45 18922.58 NA
##
## $eff.prec
## [,1] [,2] [,3] [,4] [,5] [,6]
## [1,] NA 319.8832 345.1657 381.1067 375.3234 252.3803
## [2,] 319.8832 NA 397.4992 430.7574 596.8802 332.7694
## [3,] 345.1657 397.4992 NA 1014.1278 515.8685 436.8640
## [4,] 381.1067 430.7574 1014.1278 NA 520.4834 521.7865
## [5,] 375.3234 596.8802 515.8685 520.4834 NA 329.1284
## [6,] 252.3803 332.7694 436.8640 521.7865 329.1284 NA
## Random-effects model used (moderate heterogeneity assumed).
## Power: 40.76%
## event1 n1 event2 n2 event3 n3 treat1 treat2 treat3
## 1 9 140 23 140 10 138 A C D
## 2 11 78 12 85 29 170 B C D
## 3 75 731 363 714 NA NA A C
## 4 2 106 9 205 NA NA A C
## 5 58 549 237 1561 NA NA A C
## 6 0 33 9 48 NA NA A C
## 7 3 100 31 98 NA NA A C
## 8 1 31 26 95 NA NA A C
## 9 6 39 17 77 NA NA A C
## 10 79 702 77 694 NA NA A B
## 11 18 671 21 535 NA NA A B
## 12 64 642 107 761 NA NA A C
## 13 5 62 8 90 NA NA A C
## 14 20 234 34 237 NA NA A C
## 15 0 20 9 20 NA NA A D
## 16 8 116 19 149 NA NA A B
## 17 95 1107 143 1031 NA NA A C
## 18 15 187 36 504 NA NA A C
## 19 78 584 73 675 NA NA A C
## 20 69 1177 54 888 NA NA A C
## 21 20 49 16 43 NA NA B C
## 22 7 66 32 127 NA NA B D
## 23 12 76 20 74 NA NA C D
## 24 9 55 3 26 NA NA C D
## study treatment sampleSize responders
## 1 1 A 140 9
## 2 1 C 140 23
## 3 1 D 138 10
## 4 2 B 78 11
## 5 2 C 85 12
## 6 2 D 170 29
## 7 3 A 731 75
## 8 3 C 714 363
## 9 4 A 106 2
## 10 4 C 205 9
## 11 5 A 549 58
## 12 5 C 1561 237
## 13 6 A 33 0
## 14 6 C 48 9
## 15 7 A 100 3
## 16 7 C 98 31
## 17 8 A 31 1
## 18 8 C 95 26
## 19 9 A 39 6
## 20 9 C 77 17
## 21 10 A 702 79
## 22 10 B 694 77
## 23 11 A 671 18
## 24 11 B 535 21
## 25 12 A 642 64
## 26 12 C 761 107
## 27 13 A 62 5
## 28 13 C 90 8
## 29 14 A 234 20
## 30 14 C 237 34
## 31 15 A 20 0
## 32 15 D 20 9
## 33 16 A 116 8
## 34 16 B 149 19
## 35 17 A 1107 95
## 36 17 C 1031 143
## 37 18 A 187 15
## 38 18 C 504 36
## 39 19 A 584 78
## 40 19 C 675 73
## 41 20 A 1177 69
## 42 20 C 888 54
## 43 21 B 49 20
## 44 21 C 43 16
## 45 22 B 66 7
## 46 22 D 127 32
## 47 23 C 76 12
## 48 23 D 74 20
## 49 24 C 55 9
## 50 24 D 26 3
|
treat1
|
treat2
|
treat3
|
event1
|
n1
|
event2
|
n2
|
event3
|
n3
|
|
A
|
C
|
D
|
9
|
140
|
23
|
140
|
10
|
138
|
|
B
|
C
|
D
|
11
|
78
|
12
|
85
|
29
|
170
|
|
A
|
C
|
|
75
|
731
|
363
|
714
|
|
|
|
A
|
C
|
|
2
|
106
|
9
|
205
|
|
|
|
A
|
C
|
|
58
|
549
|
237
|
1561
|
|
|
|
A
|
C
|
|
0
|
33
|
9
|
48
|
|
|
|
A
|
C
|
|
3
|
100
|
31
|
98
|
|
|
|
A
|
C
|
|
1
|
31
|
26
|
95
|
|
|
|
A
|
C
|
|
6
|
39
|
17
|
77
|
|
|
|
A
|
B
|
|
79
|
702
|
77
|
694
|
|
|
|
A
|
B
|
|
18
|
671
|
21
|
535
|
|
|
|
A
|
C
|
|
64
|
642
|
107
|
761
|
|
|
|
A
|
C
|
|
5
|
62
|
8
|
90
|
|
|
|
A
|
C
|
|
20
|
234
|
34
|
237
|
|
|
|
A
|
D
|
|
0
|
20
|
9
|
20
|
|
|
|
A
|
B
|
|
8
|
116
|
19
|
149
|
|
|
|
A
|
C
|
|
95
|
1107
|
143
|
1031
|
|
|
|
A
|
C
|
|
15
|
187
|
36
|
504
|
|
|
|
A
|
C
|
|
78
|
584
|
73
|
675
|
|
|
|
A
|
C
|
|
69
|
1177
|
54
|
888
|
|
|
|
B
|
C
|
|
20
|
49
|
16
|
43
|
|
|
|
B
|
D
|
|
7
|
66
|
32
|
127
|
|
|
|
C
|
D
|
|
12
|
76
|
20
|
74
|
|
|
|
C
|
D
|
|
9
|
55
|
3
|
26
|
|
|
|
study
|
treatment
|
sampleSize
|
responders
|
|
1
|
A
|
140
|
9
|
|
1
|
C
|
140
|
23
|
|
1
|
D
|
138
|
10
|
|
2
|
B
|
78
|
11
|
|
2
|
C
|
85
|
12
|
|
2
|
D
|
170
|
29
|
|
3
|
A
|
731
|
75
|
|
3
|
C
|
714
|
363
|
|
4
|
A
|
106
|
2
|
|
4
|
C
|
205
|
9
|
|
5
|
A
|
549
|
58
|
|
5
|
C
|
1561
|
237
|
|
6
|
A
|
33
|
0
|
|
6
|
C
|
48
|
9
|
|
7
|
A
|
100
|
3
|
|
7
|
C
|
98
|
31
|
|
8
|
A
|
31
|
1
|
|
8
|
C
|
95
|
26
|
|
9
|
A
|
39
|
6
|
|
9
|
C
|
77
|
17
|
|
10
|
A
|
702
|
79
|
|
10
|
B
|
694
|
77
|
|
11
|
A
|
671
|
18
|
|
11
|
B
|
535
|
21
|
|
12
|
A
|
642
|
64
|
|
12
|
C
|
761
|
107
|
|
13
|
A
|
62
|
5
|
|
13
|
C
|
90
|
8
|
|
14
|
A
|
234
|
20
|
|
14
|
C
|
237
|
34
|
|
15
|
A
|
20
|
0
|
|
15
|
D
|
20
|
9
|
|
16
|
A
|
116
|
8
|
|
16
|
B
|
149
|
19
|
|
17
|
A
|
1107
|
95
|
|
17
|
C
|
1031
|
143
|
|
18
|
A
|
187
|
15
|
|
18
|
C
|
504
|
36
|
|
19
|
A
|
584
|
78
|
|
19
|
C
|
675
|
73
|
|
20
|
A
|
1177
|
69
|
|
20
|
C
|
888
|
54
|
|
21
|
B
|
49
|
20
|
|
21
|
C
|
43
|
16
|
|
22
|
B
|
66
|
7
|
|
22
|
D
|
127
|
32
|
|
23
|
C
|
76
|
12
|
|
23
|
D
|
74
|
20
|
|
24
|
C
|
55
|
9
|
|
24
|
D
|
26
|
3
|
